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Unique Alternatives for Patients in Need

Colistimethate
Colistimethate is indicated for the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli. It is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa. This antibiotic is not indicated for infections due to Proteus or Neisseria. Colistimethate has proven clinically effective in treatment of infections due to the following gram-negative organisms: Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Colistimethate may be used to initiate therapy in serious infections that are suspected to be due to gram-negative organisms and in the treatment of infections due to susceptible gram-negative pathogenic bacilli. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Colistimethate and other antibacterial drugs, Colistimethate is to be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

Collatamp®
Collatamp® is a lyophilized collagen implant impregnated with the aminoglycoside antibiotic gentamicin. Collatamp® is absorbed quickly and completely and it is not necessary to remove it. Collatamp® is used for surgical implant to treat or reduce the risk of surgical site infections. Collatamp® is also used for local haemostasis of capillary, parenchymatous and seeping haemorrhages in areas with a high risk of infection. High concentration of gentamicin are delivered directly to target tissue providing highly concentrated and localized antibiotic action while maintaining systemic levels well below the toxicity threshold. There are more than 40 clinical studies evaluating the performance of Collatamp®, either for treating localized infection or for preventing surgical site infections across a wide variety of surgical procedures. Collatamp® is marketed in Latin America under the following tradenames: Collatamp®

Entocort™ Capsules1
Entocort™, is indicated for the treatment of Crohn’s disease involving the ileum and/or ascending colon. Entocort™ is a modified release capsule that contains 3mg of budesonide. It has a high topical glucocorticosteroid activity. Its formulation contains granules which are coated to protect dissolution in gastric juice, but dissolves at pH>5.5, this is normally when the granules have reached the duodenum. Thereafter, a matrix of ethylcellulose with budesonide controls the release of the drug into the intestinal lumen in a time-dependent manner.

Entocort™ Enema1
Entocort™ Enema, is indicated in the management of ulcerative colitis involving the rectum, the sigmoid and the descending colon. It is designed to provide high topical anti-inflammatory potency in patients with distal ulcerative colitis (UC). After rectal administration, absorption of budesonide is rapid and essentially terminated within 3 hours. At recommended doses, Entocort™ Enema causes no clinically important changes, neither in basal plasma cortisol levels nor in the response to stimulation with ACTH (Adrenocorticotropic Hormone).

Nitronal®
Nitronal®, is a glyceryl trinitrate solution for infusion. It is used only in hospitals for the following conditions:
– Severe unstable angina with angiospasm (in pre-infarction stage or in evolving infarction).
– Acute myocardial infarction (AMI).
– Acute pulmonary edema, associated with acute myocardial infarction.
– Acute left ventricular failure. Congestive heart failure, associated to AMI.
– Hypertensive crisis with cardiac decompensation. Catheter-induced coronary spasm.

It is also indicated to increase ischemia-tolerance during percutaneous transluminal coronary angioplasty, for hypertension management during cardiac surgery and as a uterine-muscle relaxant (for manual removal of retained placenta). Nitronal® is also marketed under the tradename Angiopohl.

Zelmac® (30 & 60 Caps)
Zelmac® (tegaserod maleate) is indicated for the short-term treatment of women less than 65 years of age with irritable bowel syndrome with constipation (IBS-C). Tegaserod is a 5-HT4 receptor partial agonist that binds with high affinity at human 5-HT4 receptors. Tegaserod, by acting as an agonist at neuronal 5-HT4 receptors, triggers the release of further neurotransmitters such as calcitonin gene-related peptide from sensory neurons. The activation of these receptors in the gastrointestinal tract serves to stimulate the peristaltic reflex and intestinal secretion, as well as inhibits visceral sensitivity. In vivo studies showed that tegaserod enhanced basal